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I (alas) have no specific advice. I may have a couple of things worthy of consideration, though.

Is there any suitable role in Cambridge that would be an (up/side)grade of your existing academic role? If so, taking that role would not be "throw it all in and end up in a support role", it would be "changing from one research role to another, in order to be close to your loved ones", which I understand is a Thing in academia (once you've stopped the chasing from one institution to another, so as to follow where the grant monies are).

There's also the fact that looking for a new job is perfectly normal (at least in IT, which is pretty much the only thing I've worked with, in multiple "industry sectors", including, but not limited to, "medical (research, education, delivery)", "music" and "interwebz"). It may well be less so in academia, but it certainly is a Thing in more IT-related academia (with people transiting somewhat seamlessly out of, and occasionally in to, academia on one hand and "the industry" on the other).